Science

The science behind VIVO

From the ear to the brain to pain relief – this is how VIVO works. Here, you can find scientific findings on auricular vagus nerve stimulation (aVNS) and the latest results from clinical studies.

Relevant studies and publications

International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020) Download-Icon
Author
Year
Journal
Farmer et al.
2021
Frontiers in Human Neuroscience
Bursted auricular vagus nerve stimulation alters heart rate variability in healthy subjects Download-Icon
Author
Year
Journal
Széles et al.
2021
Physiological Measurement
Clinical Effectiveness of Percutaneous Auricular Vagus Nerve Stimulation in Chronic Back Pain Patients – A Single-Centre Retrospective Analysis Download-Icon
Author
Year
Journal
Széles et al.
2021
Annals of Pain Medicine
High-Resolution Episcopic Imaging for Visualization of Dermal Arteries and Nerves of the Auricular Cymba Conchae in Humans Download-Icon
Author
Year
Journal
Dabiri et al.
2020
Frontiers in Neuroanatomy
Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective Download-Icon
Author
Year
Journal
Kaniusas et al.
2019
Frontiers in Neuroscience
Current Directions in the Auricular Vagus Nerve Stimulation I – A Physiological Perspective Download-Icon
Author
Year
Journal
Kaniusas et al.
2019
Frontiers in Neuroscience
Device development guided by user satisfaction survey on auricular vagus nerve stimulation Download-Icon
Author
Year
Journal
Kampusch et al.
2016
Current Directions in Biomedical Engineering
The Short- and Long-Term Benefit in Chronic Low Back Pain Through Adjuvant Electrical Versus Manual Auricular Acupuncture Download-Icon
Author
Year
Journal
Sator-Katzenschlager et al.
2004
Anesthesia & Analgesia

EU funding in the scope of Horizon 2020

In our ongoing EU Horizon 2020 project, we are developing an innovative, patient-focused pain management system based on the electrical stimulation of the vagus nerve in the ear. The developed device is a minimally invasive wearable that uses physiological feedback, such as heart rate, to individually adjust the treatment to the patient. A smartphone app for the documentation of the treatment enables complete integration in an online therapy management system.

This paves the way for the objective documentation of treatment outcomes and the personalised treatment of chronic pain based on the individual condition and dynamic requirements of the patient.

The main aim of this EU-backed project is to verify the clinical safety, performance and usability of the development in patients with chronic back pain.

Research pipeline

We are continuously working on new, effective, personalised and drug-free methods of pain relief in order to improve the quality of life of patients in the long term. We do so by developing new technologies and applications. Alongside VIVO, our first device on the market for providing personalised aVNS, we are working on a digital pain diary as well as on an integrated pain management system for the objective, personalised treatment of chronic pain.

Research pipeline